Indirect induction of lymphomas in irradiated mice. I. Tumor incidence and morphology in mice bearing nonirradiated thymic grafts.

نویسندگان

  • H S KAPLAN
  • W H CARNES
  • M B BROWN
  • B B HIRSCH
چکیده

. 4 C. P. Rhoads. Cancer Quackery : Guest Editorial 373 @ Paul Kotin. The Role of Atmospheric Pollution in the Pathogenesis of Pulmonary Cancer : A Review 375 Joseph D. Sherman and Donald I. Patt. Blood Cell Factors and Tumor Growth in the Cheek Pouch of the Golden Hamster (Mesocricetus auratus) 394 Lawrence Burton, Morris H. Harnly, and M. J. Kopac. The Activity of a Tumor Factor in Drosophila Development 4O@ Peter A. Herbut and William H. Kraemer. Heterologous Transplantation of Human Tumors 408 Harold G. Loeb, William D. Wright, and Byron E. Hall. Nucleic Acid Analysis of Human Bone Marrow Particles in Malignancy 413 James A. Green. The Effect of Hormone Administration on the Growth, Morphology, and Secre tion of a Transplanted Mouse Granulosa-Cell Tumor 417 @ Henry S. Kaplan, William H. Carnes, Mary B. Brown, and Barbara B. Hirsch. Indirect Induction of Lymphomas in Irradiated Mice. I. Tumor Incidence and Morphology in Mice Bearing Nonirradiated Thymic Grafts 49@ Henry S. Kaplan, Mary B. Brown, Barbara B. Hirsch, and William H. Carnes. Indirect Induction of Lymphomas in Irradiated Mice. II. Factor of Irradiation of the Host . . . 4@6 William H. Carnes, Henry S. Kaplan, Mary B. Brown, and Barbara B. Hirsch. Indirect Induction of Lymphomas in Irradiated Mice. III. Role of the Thymic Graft 4@9 Henry S. Kaplan, Barbara B. Hirsch, and Mary B. Brown. Indirect Induction of Lymphomas in Irradiated Mice. IV. Genetic Evidence of the Origin of the Tumor Cells from the Thymic Grafts 434 Dwight J. Ingle, Tomas L. Altamero, Jr., and Violeta Flores. Weights of Tumors in Overfed Rats 437 B. S. Oppenheimer, Enid T. Oppenheimer, I. Danishefsky, and Arthur Purdy Stout. Car cinogenic Effect of Metals in Rodents 439 Charles Heidelberger and Marjorie G. Moldenhauer. The Interaction of Carcinogenic Hydro carbons with Tissue Constituents. IV. A Quantitative Study of the Binding to Skin Proteins of Several C'4-labeled Hydrocarbons 44@ A. H. Conney, E. C. Miller, and J. A. Miller. The Metabolism of Methylated Aminoazo Dyes. V. Evidence for Induction of Enzyme Synthesis in the Rat by 3-Methyicholanthrene . . 450 Borroughs R. Hill. Some Properties of Serum Lactic Dehydrogenase 460 Announcements 467

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Effect of hypothyroidism and thyroid grafts on lymphoid tumor development in irradiated C57BL mice.

Endocrine factors condition susceptibility of some strains of mice to the induction of lymphoid tumors by various carcinogenic agents (reviews by Kaplan et a/. [14], Gardner eta/. [6]). In previous work adrenalectomy or orchiectomy augmented, whereas cortisone, hydrocortisone, or testosterone inhibited, the leukemogenic process (9, 10, 13). Hypophysectomy failed to influence the incidence of ra...

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Effect of Hypothyroidism and Thyroid Grafts on Lymphoid Tumor Development in Irradiated C57BL Mice*

Endocrine factors condition susceptibility of some strains of mice to the induction of lymphoid tumors by various carcinogenic agents (reviews by Kaplan et a/. [14], Gardner eta/. [6]). In previous work adrenalectomy or orchiectomy augmented, whereas cortisone, hydrocortisone, or testosterone inhibited, the leukemogenic process (9, 10, 13). Hypophysectomy failed to influence the incidence of ra...

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Reconfirmation of indirect induction of radiogenic lymphomas using thymectomized, irradiated B10 mice grafted with neonatal thymuses from Thy 1 congenic donors.

An experiment was conducted to reexamine earlier observations that lymphomas could develop from lymphocytes present in nonirradiated thymuses grafted into thymectomized, fractionally (170 R, 4 doses) irradiated mice by using B10. Thy 1 congenic donor-host combinations. The results indicated that: (a) 37 of 91 thymectomized, fractionally irradiated B10. Thy 1.2 mice which were grafted s.c. with ...

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Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen

The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b) the induction of T cell lymphomas of host origin in mice infused with bone marrow from irradiated, Thy-l-congenic donors. The latter procedure a...

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Indirect induction of lymphomas in irradiated mice. III. Role of the thymic graft.

that lymphoid tumors arise in nonirradiated thy mic grafts implanted into previously thymecto mized, irradiated CS7BL mice. This phenomenon provides a unique experimental model for the study of those components of the tumor-inducing mechanism which are intrinsic properties of the graft, as distinguished from those which are mcdi ated through its environment, the host. Irradia tion of the host i...

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عنوان ژورنال:
  • Cancer research

دوره 16 5  شماره 

صفحات  -

تاریخ انتشار 1956